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Additional studies have determined PT-141 is a potential remedy for the treatment of sexual dysfunction

HDAC-6 interacts with and deacetylates tubulin and microtubules in vivo

The elevated expression of 20S proteasome (increased PSMA6), which play an important role in the elimination of oxidized proteins, might be one of the mechanisms that account for reduced levels of oxidized proteins in male livers

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In this respect, 300 nM Ex-4 during differentiation reduced lipid accumulation and downregulated the adipogenic markers PPAR , FABP4 , whereas early exposure at cell isolation or prior to induction increased these markers, indicating pro-adipogenic priming effects