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Using optogenetics and pharmacological manipulations, the authors demonstrated that GLP-1Rexpressing GABAergic neurons in the LDTg inhibit VTA dopamine neurons projecting to the NAc

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Intravenous (IV) administration is considered the most effective delivery method for both NAD+ and glutathione

They are firing in response to stimuli that normally would not trigger a strong signal

Higher doses consistently showed significant reductions in liver enzymes (AST and ALT), hepatic steatosis, and inflammation, although the effect on fibrosis was limited