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- Most evidence comes from animal studies - Human data is extremely limited - No FDA approval for orthopedic use - Clinical benefit in musculoskeletal conditions remains unproven While the biology is interesting, potential does not equal proven clinical outcomes

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If you dont treat it, low levels of B12 could lead to anemia, nerve damage, moodiness, and other serious problems

(2) The removal of the tripeptide sequence (Gly-Pro-Glu) from the N-terminus eliminates a key binding domain for IGFBPs, allowing the peptide to interact more freely with IGF-1 receptors

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