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Recruitment for Phase III clinical trials to assess the efficacy and safety of bepirovirsen is also underway, with results expected in early 2026 (NCT05630807 and NCT05630820)

Human clinical trial data is extremely limited

Simon J, Fung K, Raisi-Estabragh Z, Aung N, Khanji MY, Kolossvry M et al (2022) Light to moderate coffee consumption is associated with lower risk of death: a UK Biobank study

In the last decades, IGF-1 has been implicated in many physiological actions, among others: tissue growth and development, proliferative, lipid metabolism, pro-survival/anti-aging, anti-inflammatory, anabolic, and antioxidant with neuro- and hepatoprotective properties [105116]

These effects are usually transient and last only a short time after administration