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Even outside the context of GLP-1s, disruptions in temperature regulation and menstrual function can make exercise feel harder than usual

According to data published in e ClinicalMedicine in 2022, about one in three people with a binge eating disorder has type 2 diabetes

Semaglutide has more published data on inflammatory marker reduction

a gradual dosage increment to 14-mg once-daily oral semaglutide treatment had gastrointestinal side effects parallel to those of 1 mg of once-weekly subcutaneous semaglutide [32,33]

Potentially triggered by stress, hormonal changes, or medications affecting blood vessels, though the exact cause is unclear