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Novel roles for protein disulphide isomerase in disease states: A double edged sword

Shaking the vial can cause the delicate amino acid chains of the peptide to shear and break apart, a process called denaturation

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Mounjaro is licensed in the UK for two indications: 1 Type 2 diabetes mellitus, alongside diet and exercise, in adults with insufficient blood sugar control Chronic weight management, alongside a reduced-calorie diet and increased physical activity, in adults with a BMI of 30 kg/m or higher, or 27 kg/m or higher with at least one weight-related condition The Summary of Product Characteristics lists prediabetes as one of the weight-related conditions that qualify someone with a BMI of 27 or higher for the weight management licence