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In contrast, in normal non-cancer rectal tissue, metformin significantly altered the secretion of only three IL-17 related cytokines, suggesting that metformin differentially alters the inflammatory secretome of normal rectal tissue, when compared to rectal cancer tissue, which may support its potential utility as a radiosensitiser

If symptoms are being driven by low testosterone or other hormone imbalances, hormone testing may reveal a larger underlying issue

These metabolic changes are generally favorable from an insurance underwriting perspective but should be disclosed honestly to the examining physician so results are interpreted in proper context

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Lett ., 12 , 2560-2566, doi: 10.3892/ol.2016.4978