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Some patients experience mild redness, swelling, or itching at the injection site within minutes to hours, but these reactions are typically minimal and resolve within a few hours without treatment

The first approved GLP-1 analogue for clinical use was exenatide in 2005, a peptide originally isolated from Heloderma suspectum lizard venom by John Eng in 1992 [17]

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However, Ozempic is not FDA-approved for PCOS, insurance may not cover it, and women should stop the medication at least two months before trying to conceive