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However, across many checkpoint-focused AD studies that primarily target oxidative stress, A clearance, or neuroinflammatory checkpoints, the field has only rarely measured a complete ferroptosis signaturethat is, simultaneous assessment of iron-dependent lipid peroxidation together with GPX4/SLC7A11 and ACSL4/LPCAT3 alterations, combined with ferroptosis-selective rescue experiments (e.g., ferrostatin-1, liproxstatin-1, or FSP1 activation)

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10.1056/NEJM200105103441904 49 NiuZ.Conejos-SnchezI.GriffinB

[DOI] [PMC free article] [PubMed] [Google Scholar] 31.Sekine H., Okazaki K., Ota N., Shima H., Katoh Y., Suzuki N., Igarashi K., Ito M., Motohashi H., Yamamoto M