best location to inject semaglutide How Best Injection Sites for Semaglutide:

(13) Preclinical studies have demonstrated that GLP-1 receptor agonists like exenatide can enhance bone mass in diabetic and insulin-resistant rat models by upregulating OPG expression and improving the OPG/RANKL ratio

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If fatigue is the problem, morning injections may be preferable so the tired phase hits in the evening when you would be winding down anyway

Metformin inhibits the production of reactive oxygen species from NADH: ubiquinone oxidoreductase to limit induction of interleukin-1 (IL-1) and boosts interleukin-10 (IL-10) in lipopolysaccharide (LPS)-activated macrophages

GLP-1 also has beneficial effects on metabolism, helping the body use energy more efficiently