The identified mechanisms include: Competitive Reuptake Inhibition: Amphetamine enters the presynaptic neuron either by passive diffusion or by acting as a competitive substrate for the plasma membrane monoamine transporters
Most people see initial results within the first week , with significant changes becoming apparent by weeks four to eight as steady state is established
Wright JT Jr, Williamson JD, Whelton PK, Snyder JK, Sink KM, Rocco MV, Reboussin DM, Rahman M, Oparil S, Lewis CE, Kimmel PL, Johnson KC, Goff DC Jr, Fine LJ, Cutler JA, Cushman WC, Cheung AK, Ambrosius WT
In its trials, those without type 2 diabetes who received Wegovy lost an average of 12.4% of their initial body weight compared to individuals who received a placebo
E.BendersM.GonzalezF.BearerC.et al (2023)