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This accumulation contributes to progressive auditory and vestibular dysfunction, which can manifest as irreversible SHL or balance disturbances

At the same time, key survival-related pathways, including AMPK/SIRT1/PGC-1 and IGF-1/PI3K/Akt, were upregulated, indicating improved mitochondrial function and neuronal resilience

Body weight was measured every five days for the 60-day duration, while the mice were undergoing behaviour tests

Cao C, Xiao Z, Wu Y, Ge C

This work may also bring new insights into diseases that alter body composition, such as obesity, type 2 diabetes, adult GHD, acromegaly and glucocorticoid excess