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Appears or worsens after a dose increase

Phosphorylation and positive regulation of the phosphorylation process are usually involved in cell growth, apoptosis and signaling pathways through post-translational modification and cellular metabolism, and abnormal alteration in phosphorylation contribute to diseases, including cancers 29

Other considerations: The presence of key enzymes as isoenzymes in different tissues and cells underscores the versatility and adaptability of metabolic pathways

If switching the route of administration and dosage don't help, you may also have like a substrate issue

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