intestinal microbiota metabolism of l carnitine Revisiting the Role in Heart Disease Through the Lens of the Gut Gut microbe-derived metabolite trimethylamine N-oxide

10.1038/s41598-018-25603-5 Sci

Clinical trials evaluating SGLT2 inhibitors in patients with coronary microvascular dysfunction have shown improvements in coronary flow reserve through mechanisms involving ferroptosis inhibition (86)

This is because ketone body defects inhibit lipid oxidation by inhibiting -hydroxybutyrylation, which prevents the metabolic flow from acetyl-coenzyme A delivery to the ketone bodies (72), thereby echoing the previously discussed inhibition of cardiac proliferation and regeneration by fatty acid metabolism

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Recovery from hypogonadism in men with prolactinoma treated with dopamine agonists