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Acknowledgements The authors acknowledge Matthew Wither for generating the untargeted liver metabolomics data

Yet, as the years pass, many of us notice a subtle but undeniable shift

Vial size selection should be guided by the specific reconstitution volume stated in the drug product's prescribing information

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Note that the TB-500 name has historically been applied both to the full 43-residue protein and, as documented by Ho and colleagues (J Chromatogr A, 2012), to preparations containing only the LKKTETQ heptapeptide

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