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IGF-1 elevation: Mean IGF-1 levels increased 1.5 to 3-fold above baseline and remained improved for up to 28 days after dosing

This is a glucagon receptor-mediated effect not seen with semaglutide

Extrapyramidal symptoms may occur more often with depot preparations of first-generation antipsychotics than with the corresponding oral preparations

J Alzheimers Dis 26:387408 Gao Y, Xie X, Zhang X, Cao J, Lan W, You T et al (2025) Substrate recognition and cleavage mechanism of the monkeypox virus core protease

Given modulatory potential of IFNs to initiate or amplify immune responses leading to organ damage in lupus, this cytokine system became an excellent therapeutic target