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For example, one clinical study found that pre-injecting 0.9% benzyl alcohol solution (bacteriostatic saline) greatly reduced propofol injection pain compared to placebo

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A reasonable titration schedule might look like this: Week 1: 200mcg once daily Week 2: 300mcg once daily Week 3 onward: 300-500mcg based on response and tolerance Optimizing injection technique Poor injection technique contributes to injection site reactions and potentially to other effects like nausea from anxiety around the process

Headache in the first 1-3 doses

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