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When initiating semaglutide in patients already on insulin, insulin doses should be reduced gradually and carefully to avoid diabetic ketoacidosis (DKA)

The broader implications extend beyond semaglutide

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More than 100 preclinical studies have examined the peptide in models of gut injury, tendon and ligament repair, blood vessel formation, and nervous system damage

Use hot water for cleansing, as it can cause skin dehydration and sensitivity