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According to the diagnostic interval between type 2 diabetes mellitus (T2DM) and PDA, DM was divided as the long-standing diabetes mellitus (time interval longer than 3 years) and the new-onset diabetes mellitus (time interval shorter than 3 years) (Jeon et al., 2018)

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This recognition inappropriately activates the immune system, triggering pathological inflammation via the cytosolic c-GAS-STING sensing pathway, leading to aberrant cytokine expression and proinflammatory immune cell recruitment in diabetes (Riley and Tait, 2020)