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Fertility And Sterility, 83(2), 355-361

[5] Howes RE, et al

The most commonly cited starting protocol in the medical literature and clinical practice involves 250 micrograms administered once daily for acute injury, stepping up to 500 micrograms daily if response is insufficient after one to two weeks

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The increase in ROS or RNS levels involves a concomitant increase of proinflammatory cytokines and the activation of NF-, which in turn activates the hepatic stellate cells, the subsequent fibrosis, and damage to the DNA [12,64], with a failure in the synthesis of exogenous antioxidants [12]