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It has a close relationship with osteoclastogenesis, metastasis, and tumor invasion

[DOI] [PMC free article] [PubMed] [Google Scholar] 38.Biondi B, Cappola AR, Cooper DS

Indeed metformin inhibits the mitochondrial oxidative phosphorylation complex I, leading to increased cellular AMP levels and subsequent stimulation of AMPK, an enzyme that plays key roles in the regulation of cellular energy homeostatis

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