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Parathyroid hormone (PTH) upregulates CYP27B1 and downregulates CYP24A1 to promote active Vitamin D synthesis, whereas fibroblast growth factor 23 (FGF23) exerts opposing effects [97, 98].Additionally, serum phosphate, calcium levels, and 1,25(OH)D itself participate in feedback regulation, creating a dynamic and complex endocrine network [94]

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