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There is some evidence for a temporal window of TABLE 3-6 Examples of Experimental Models of Repetitive TBI vulnerability, with repeated mild injuries in close temporal proximity producing greater damage than injuries separated by longer periods of time (in the case of rodents, a separation of seven days) (Longhi et al., 2005)
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Insulin-like growth factors and their binding proteins: Biological actions
This decline leads to insufficient activation of sirtuins (SIRT1SIRT7)NAD+-dependent deacetylases that regulate mitochondrial biogenesis via PGC-1, DNA repair, and cellular stress resistance
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