for example, activating the leptin receptor to modulate energy homeostasis, e.g., reducing appetite while also blocking the response signal to reduce energy expenditure to enhance weight loss, utilise fat stores and thus preserve muscle
Pharma is innovating to hit even more targets The latest article I saw about the work being done in this class is a study in mice looking at a quintuple agonist (5 different targets!) I almost never write about mice studies because of how preliminary they are and how unlikely a finding in mice is to ever translate into anything useful in humans, but because of the success weve already seen of this drug class as well as the way that hitting more pathways seems to increase efficacy, I thought this was research worth highlighting
Strain Evidence: What Clinical Research Shows Not all probiotics are interchangeable
Clinical trials show Contrave-treated patients lost approximately 59% of body weight over 56 weeks
Additionally, there are potential side effects including allergic reactions, kidney damage and potentially harmful interactions with other medications or conditions
