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We then performed sequence alignment of PDS5B 1308-1394 against the equivalent region in several PDS5B orthologs to identify conserved lysine and arginine residues that could be involved in interactions with the negatively charged phosphodiester backbone of DNA

Serious Adverse Effects Overdose toxicity: Extremely high doses of alpha-lipoic acid (6,000 mg or more in a single day) can result in overdose, causing nausea, drowsiness, mental confusion, seizures, shock, organ failure, and death

The applicant also noted Anderson et al

In this review article, the authors have provided a detailed overview of these strategies

K.Natural toxins and their therapeutic potential.2010228 EOF37 EOF