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A high-purine diet, alcohol consumption, and high fructose intake increase uric acid synthesis, while metabolic disorders and insulin resistance further disrupt the homeostasis of uric acid metabolism

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Reactive astrogliosis plays essential roles in both attracting and containing neuroinflammation, and is critical for wound closure, fibrotic scar formation, erecting glia limitans barrier delineating the damaged tissue and supporting postlesional regeneration and plasticity

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