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GLP-1 RAs, including semaglutide, have been previously associated with exocrine pancreatic effects, primarily acute pancreatitis
Lebeau PF, Byun JH, Platko K, Saliba P, Sguazzin M, MacDonald ME et al (2022) Caffeine blocks SREBP2-induced hepatic PCSK9 expression to enhance LDLR-mediated cholesterol clearance
Meanwhile, in a 12-week phase 2 trial with moderate dose-escalation regimens, gastrointestinal tolerability improved when starting with a lower dose and slowly increasing to the highest effective doses [55]