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For weekly medications, the timing has less impact on side effects due to their steady-state pharmacokinetics

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In clinical trials examining GLP-1 RA in combination with a sulphonylurea (with or without metformin) or insulin, the incidence of hypoglycemia was low overall, but increased when compared with placebo [114]

Semaglutide is also now indicated to reduce liver fibrosis in patients with metabolic fatty liver disease, making it one of the few medications with benefits that extend well beyond weight loss

Another practical observation is that many people regain weight once the medication is stopped, suggesting the underlying metabolic drivers may not have been fully addressed