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In particular, glucagon has firmly been demonstrated to enhance hepatic lipid metabolism, Hepatic GCGR agonism leads to upregulation of lipid catabolism pathways in the hepatocyte where a number of key regulatory transporters and enzymes facilitate beta oxidation of fatty acids (61)

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doi: 10.1016/j.scitotenv.2020.137907 83 ParkMDSilvinAGinhouxFMeradM

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Continuous activation of c-Met receptors without recovery periods may lead to receptor internalization and reduced surface expressiona protective mechanism cells employ when signaling pathways are overstimulated