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This dual action can further suppress appetite and amplify weightloss signals in the brain

Semaglutide and liraglutide effects on central nervous system regulation GLP-1 and GLP-1RA are involved in the activation of various central nervous system (CNS) processes, including satiety, thermogenesis, blood pressure, neurogenesis, and inflammation reduction (15)

At the 24-week mark, the mean increases in heart rate were: 1 mg dose: +4.1 bpm 4 mg dose: +6.1 bpm 8 mg dose: +7.9 bpm 12 mg dose: +7.8 bpm These increases were observed to be maximal around 24 weeks and then showed a slight attenuation, though they remained elevated above baseline for the entire 48-week study period

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