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In addition to its metabolic effects, GLP-1 acts centrally to maintain energy balance by activating glucagon-like peptide-1 receptors (GLP-1Rs) located in key regions of the brain
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Nausea, bloating, constipation, and reflux are common, especially during dose increases
While more research is necessary, repeated exposure to oscillatory hemodynamic stress and the associated patterns of shear stress on the endothelium may prime the vasculature to better handle both surges and sudden drops in systemic blood pressure, potentially leading to better maintenance and regulation of CBF during pressure challenges
In Figure6 we showed that an overdose of APAP (corresponding to 200 mg/kg, or a 12 g dose for a 60 kg person) depletes liver GSH severely after 2 hours
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