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They promote lipid, protein, and DNA oxidation, forming cytotoxic products such as malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE), which compromise mitochondrial DNA and disrupt electron transport, especially at complexes I and III (Wang et al., 2024)
It confirmed that the dual GIP/GLP-1 mechanism of tirzepatide offers a meaningful clinical advantage over GLP-1-only medications for weight loss
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Both medications have similar list prices at standard retail
In the USA, Mounjaro is FDA-approved for type 2 diabetes management
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