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Despite more than 500 published preclinical studies (primarily animal and cell-culture models from Sikiric and colleagues at the University of Zagreb), there have been essentially no registered human clinical trials for BPC-157 in the United States

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Hypoglycemic drugs such as metformin, SGLT2i, DPP-4i, GLP-1RA, anti-inflammation therapies, anti-senescence therapies, mineralocorticoid receptor antagonists, and stem cell therapies have also shown beneficial effects against tubular injury, potentially slowing the progression of the DKD, and thereby protecting the kidney