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However, despite the majority of individuals with type 2 diabetes being overweight or obese [7, 8], no clinical study has investigated the possibility of preventing disability after stroke in type 2 diabetes by normalising body weight before stroke

JAMA Health Forum 2025;6:e245586

The FDA has limited experience with accelerated approvals based on intermediate clinical endpoints, but has indicated that such endpoints generally may support accelerated approval where the therapeutic effect measured by the endpoint is not itself a clinical benefit and basis for traditional approval, if there is a basis for concluding that the therapeutic effect is reasonably likely to predict the ultimate clinical benefit of a product

Some people may find that their usual coffee intake affects them differently once they begin Mounjaro, especially during the initial titration phase when the body is adjusting to the medication