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Reconstitute 2.5 mL BAC water Concentration 5.0 mg/mL reta + 1.0 mg/mL cag Weekly draw range 0.40-2.40 mL (40-240 units) Typical cycle 24-week ramp + maintenance Dose selector Component Delivery (12.5/2.5 mg Blend) * Volumes above 100 units exceed a standard 1 mL insulin syringe - split into two injections or use a larger syringe

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Populations of particular concern based on mechanism and the absence of human data include: individuals with active or suspected malignancy (pro-angiogenic preclinical profile)

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