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doi: 10.1111/nph.18728 50 NoctorG.FoyerC

Ferrostatin-1 potently inhibits the release of high mobility group box protein (HMGB)-1, a classical marker of necroinflammatory response, in cell models and human skin explants after UVB irradiation, thus confirming that ferroptosis is a key element of the necroinflammatory process in keratinocytes

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For example, the protein products of the CISD1 and CISD2 genes, MitoNEET and NAF-1, respectively, act together to transport ISCs into mitochondria