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Este texto completo es la transcripcin editada y revisada de una conferencia dictada en el marco de las reuniones clnicas de la Unidad General de Cuidados del Nio del Hospital Padre Hurtado
Ozkurt, Y
1 Introduction There are many pine bark extracts on the market, from different pine tree species, from different countries and with different levels of efficacy for human health ( French maritime pine bark extract (Horphag Research) is the most researched pine bark extract with over 450 published studies and over 160 human clinical trials, including over 12.000 subjects ( The French maritime pine trees that are used for Pycnogenol grow in Les Landes de Gascogne, along the coast of southwest France ( Pycnogenol was found to contain mainly procyanidins, their monomers catechin and epicatechin, taxifolin as well as phenolic acids ( is standardized to 70 5% and thus meets the specifications for maritime pine extract, described in the United States Pharmacopeia (USP) ( , taxifolin, catechin, caffeic acid, ferulic acid and metabolite 1 [-(3,4-dihydroxy-phenyl)--valerolactone] have been detected in the blood plasma of volunteers ( Clinical research on Pycnogenol started over 40 years ago and various health benefits of Pycnogenol have been observed and investigated
If mild gastrointestinal discomfort occurs, dividing the total daily dose into smaller morning and afternoon portions can significantly improve tolerability while maintaining steady plasma levels
Most current claims involve severe gastrointestinal injuries such as gastroparesis, ileus, intestinal obstruction, or persistent vomiting requiring hospitalization or surgical intervention
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