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Its not about masking symptoms

Using them concurrently creates a biological tug-of-war that makes it impossible to predict the net effect

Int J Biol Macromol 293:139216

One of the possible mechanisms thought to be related to brain overgrowth is the increased blood concentrations of brain-derived neurotrophic factor (BDNF) in newborns who were later diagnosed with ASD (Hazlett et al., 2011

Topicals can be effective for around 20-60 minutes, and Vyleesi content in the body peaks at around one hour before falling again.57 Even with combining Addyi and Vyleesi, there dont appear to be any known risks of mixing these two approaches together at the time of this writing