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Klauda, J
Funding This work was supported by the Sichuan Provincial Central Government-Guided Local Science and Technology Development Project (2024ZYD0120)
Opportunities and challenges in targeting TDLNs LN-targeted immunotherapy As TDLNs are widely recognized for playing a key role in driving the immunotherapy response, it is hypothesized that the effectiveness of ICB relies predominantly on an influx of newly primed T cells into the tumor from peripheral lymphoid organs, particularly the TDLNs, rather than on reinvigorating exhausted and fully differentiated T cells that already exist in tumors (47, 52)
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Other entero-pancreatic hormones and combination of entero-pancreatic hormones in the management of obesity Numerous entero-pancreatic hormones [GIP, glucagon, amylin and peptide YY (PYY) agonists and GIP antagonists] with diverse metabolic actions are currently under investigation either alone or in combination with GLP-1 RA (Fig
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