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Following their synthesis, polyamines can be exported from cells following incorporation into secretory vesicles

* Primary study endpoint

Willy, Young, Stevens, Masuoka, & Wek, 2015) and to promote hepatocyte cell death(Iracheta-Vellve et al., 2016

DiMarchi transformed thinking about the hormones this class oftherapies should mimic, a critical part of their efficacy. Despite critics who doubted obesity was a disease at all, they relentlessly pursued this use case, well beyond being the first 2 to patent it

Psychoneuroendocrinology 36(10):15301539 Traslavia GA, Franci CR (2011) The CRH-R1 receptor mediates luteinizing hormone, prolactin, corticosterone and progesterone secretion induced by restraint stress in estrogen-primed rats