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Copper is an important cofactor for enzymes involved in: Collagen cross-linking Antioxidant defense Wound repair Extracellular matrix remodeling GHK-Cu appears to support: Collagen synthesis Elastin production Glycosaminoglycan production Angiogenesis Antioxidant activity Matrix metalloproteinase regulation Why GHK-Cu is popular in aesthetics: GHK-Cu is commonly discussed in skin rejuvenation because it may support skin thickness, elasticity, firmness, wound repair, hair follicle signaling, reduced inflammation, and improved skin texture

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Cytotoxicity of both QIs increased under GSH-depleted conditions, confirming that GSH is important as scavenger by GSH-conjugation and as endogenous antioxidant ( Figure 1 )

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