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Potential Risks and Solutions Lack of Extensive Human Trials Risk: Research on large human populations is limited, so long-term safety and efficacy remain partially unknown

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Age: Younger users (20s-30s) typically see faster results than older users (50s+), though older users often see more dramatic quality of life improvements

GLP-1R reduces oxidative damage accumulation by modulating autophagy-related proteins and scavenging damaged mitochondria while increasing superoxide dismutase (SOD) and glutathione peroxidase activities, reducing the generation of lipid peroxidation products, inhibiting the NF-B signaling pathway, and decreasing proinflammatory factor expression to reduce neuroinflammation (Ma et al., 2018

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