To exclude that NS5B mediated 5FAD capping could happen post-initiation on a 5ppp initiated RNA, 5ppp RNA was incubated with FMN in the presence of NS5B polymerase
Moreover, cancer cells often cannot synthesize sufficient Gln internally, leading to a glutamine-dependent phenomenon in which high Gln levels sustain normal cancer cell growth, whereas low Gln environments induce cell growth arrest
Note that the intracellular concentrations of Hcy, SAM, SAH, and Met all change in the same direction as seen clinically
Hypoglycemia Risk in Combination Therapy As monotherapy or in combination with metformin, GLP-1 agents carry minimal hypoglycemia risk because insulin secretion is glucose-dependent
When a drug does enough good things, theres a tendency among clinicians and patients alike to stop asking uncomfortable questions