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Romeo et al., 2015)

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MDMA has been suggested as a treatment for: post-traumatic stress disorder (PTSD) disordered eating alcohol addiction and dependency anxiety in people with a terminal illness social anxiety in autistic adults co-occurring PTSD and opioid dependency When used in a therapeutic setting, MDMA may enhance many aspects of talk therapy

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Another evidence linking the NAD + metabolism with DNA methylation is the NNMT, which transfers the methyl group from SAM to NAM, producing S-adenosylhomocysteine (SAH) and a stable metabolites 1-methylnicotinamide (MNA)