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A total of 1,961 adult participants with a BMI of at least 30 or at least 27 with at least one weight-related comorbidity were randomized to receive either semaglutide (2.4 mg) or placebo, administered subcutaneously once weekly, along with lifestyle intervention
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"Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle." Biochemical Pharmacology
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These protective effects extend beyond weight loss and likely involve semaglutide's direct action on heart and blood vessel cells
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