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L-Carnitine as a Buffer for Excess Acetyl-CoA In a reaction catalyzed by CPT I, the free form of L-carnitine binds to a fatty acid to form acyl-carnitine

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It may worsen symptoms in a folate-sensitive undermethylator or when other methylation impediments are present

Unlike its counterpart with DAC (Drug Affinity Complex), the no-DAC version has a shorter half-life, allowing for more precise control in research settings