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In vivo CRISPRa decreases seizures and rescues cognitive deficits in a rodent model of epilepsy

[DOI] [PMC free article] [PubMed] [Google Scholar] 232

One works systemically over time, and the other works more directly on healing

The study used 36 male Sprague-Dawley rat pup, exposed to 250 mg/kg PPA to induce ASD-lke features, and pre-treated for 27 days with either yogurt, artichoke extract (400 mg/kg), luteolin (50 mg/kg) or Lacticaseibacillus rhamnosus GG (0.2 mL/day)