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[DOI] [PMC free article] [PubMed] [Google Scholar] 9.Scheibenbogen C., Freitag H., Blanco J., Capelli E., Lacerda E., Authier J., Meeus M., Castro Marrero J., Nora-Krukle Z., Oltra E., et al
Remodels the Matrix: It doesn't just add collagen
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Therefore, the precise mechanisms through which lipoxygenases contribute to ferroptosis, particularly in GPX4 inhibition contexts, require further investigation ( 3.2.4 Therapeutic targets and experimental evidence Lipid peroxidation not only affects biological membrane fluidity and membrane protein function, impairing cellular activity, but its products also form reactive aldehyde end products, including 4-hydroxynonenal (4-HNE) and MDA
