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While non-activated microglia preferentially use oxidative phosphorylation, activated microglia undergo a metabolic reprogramming, with increased glucose uptake and strengthening of anaerobic glycolysis, to increase ATP production [65]

However, when another analysis was performed that removed trials at high risk of performance bias, the results werent significant

Determining causality in such cases is difficult

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Future randomized trials should evaluate iron indices, hepcidin levels, ferritin, transferrin saturation, and hemoglobin trends in patients treated with GLP-1 receptor agonists