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These molecules may offer novel mechanisms of action that are less likely to promote resistance development

184 For the folate metabolism pathway, the NADP + -dependent dehydrogenase activity of MTHFD2 and MTHFD2L can be inhibited by inorganic phosphate

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The combination is significantly more effective than either modality alone

doi: 10.3389/fphar.2026.1740609 Received 06 November 2025 Revised 03 February 2026 Accepted 11 February 2026 Published 24 February 2026 Volume 17 - 2026 Edited by Ziyi Wang, Johns Hopkins University, United States Reviewed by Xue Xiaoyong, Beijing University of Chinese Medicine, China Yatan Li, Xinjiang Medical University, China Updates Copyright 2026 Pang, Jiang, Ge, Huang, Rao, Wang, Zhou, Lyu, Wang and Tan